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. 2008 Nov;46(11):3639-45.
doi: 10.1128/JCM.00605-08. Epub 2008 Sep 24.

Mycobacterium tuberculosis population structures differ significantly on two Indonesian Islands

Ida Parwati  1 , Reinout van Crevel, Mirawati Sudiro, Bachti Alisjahbana, Trevino Pakasi, Kristin Kremer, Adri van der Zanden, Dick van Soolingen
Affiliations

Mycobacterium tuberculosis population structures differ significantly on two Indonesian Islands

Ida Parwati et al. J Clin Microbiol. 2008 Nov.

Abstract

Comparison of Mycobacterium tuberculosis genotype distributions in different areas might help to find determinants of the emergence of certain genotypes, such as the Beijing family. In this study, M. tuberculosis isolates originating from patients from two Indonesian islands were genotyped, and possible associations with patients' characteristics and drug resistance were explored. A high degree of genetic diversity was observed among the M. tuberculosis strains, and a significant difference was found in the geographical distribution of genotype families. The predominant Beijing genotype family was isolated from 268 of 813 patients from West Java (33.0%) versus 12 of 84 patients from Timor (14.3%) (P = 0.002). Family F (East African-Indian) (33.3%) and family D (Latin American and Mediterranean) (20.0%) were more prevalent in Timor. No significant associations were found between genotype families and age, vaccination with Mycobacterium bovis BCG, previous treatment, disease localization, or drug resistance. Possible explanations for the differences in the geographical distribution of the M. tuberculosis genotypes are discussed.

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Figures

FIG. 1.
FIG. 1.
Diagram of the 198 orphan spoligotype patterns found in this study, with a dendrogram on the left showing the similarities among the patterns. The number of isolates of each spoligotype is given on the right.
FIG. 2.
FIG. 2.
Distribution of M. tuberculosis genotype families in West Java and Timor. *, P < 0.05.
See this image and copyright information in PMC

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