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. 2007 Apr;3(2):59-64.
doi: 10.1007/s11888-007-0001-y.

Mitotic Origins of Chromosomal Instability in Colorectal Cancer

W Brian Dalton, Vincent W Yang

Mitotic Origins of Chromosomal Instability in Colorectal Cancer

W Brian Dalton et al. Curr Colorectal Cancer Rep. 2007 Apr.

Abstract

Mitosis is a crucial part of the cell cycle. A successful mitosis requires the proper execution of many complex cellular behaviors. Thus, there are many points at which mitosis may be disrupted. In cancer cells, chronic disruption of mitosis can lead to unequal segregation of chromosomes, a phenomenon known as chromosomal instability. A majority of colorectal tumors suffer from this instability, and recent studies have begun to reveal the specific ways in which mitotic defects promote chromosomal instability in colorectal cancer.

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Figures

Figure 1
Figure 1
Mitotic origins of chromosomal instability in colorectal cancer. This figure contains the reported genetic changes in colorectal cancer that are associated with chromosomal instability. The various phases of mitosis are shown. The genes are described in the text. Down arrows indicate either mutational inactivation or reduction in expression. Up arrows indicate overexpression. APC—adenomatous polyposis coli; CENP-H—centromere protein H.
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