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Case Reports
. 2008 Jul;31(3):435-8.

Leishmania infection can hamper immune recovery in virologically suppressed HIV-infected patients

Nicola Gianotti  1 , Myriam Maillard, Giovanni Gaiera, Arabella Bestetti, Massimo Cernuschi, Anna De Bona, Adriano Lazzarin, Paola Cinque, Simona Bossolasco
Affiliations
  • PMID: 18843901
Free article
Case Reports

Leishmania infection can hamper immune recovery in virologically suppressed HIV-infected patients

Nicola Gianotti et al. New Microbiol. 2008 Jul.
Free article

Abstract

An HIV-infected patient started combination antiretroviral therapy with 13 CD4+ cells/microL. Despite sustained virological suppression over the following four years, the anemia did not resolve, and the CD4+ cell counts always remained below 200/microL until co-infection with Leishmania was diagnosed in October 2006 when the patient started complaining of persistent mild fever and asthenia. Once treatment for leishmaniasis was started with miltefosine, CD4+ cell count rose above 400/microL. A new drop in CD4+ cell count was observed when Leishmania DNA turned out again to be positive, but treatment with liposomal amphotericin-B restored immune recovery.

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