Antiretroviral therapy during infancy: essential intervention for resource-limited settings

Abstract

EVALUATION OF: Prendergast A, Mphatswe W, Tudor-Williams G et al. Early virological suppression with three-class antiretroviral therapy in HIV-infected African infants. AIDS 22, 1333-1343 (2008). There is limited information regarding the outcome of infants treated with highly active antiretroviral therapy (HAART) in middle- and low-income countries. The mean/median age of children enrolled on HAART in these countries is generally high; however, it is acknowledged that untreated HIV-infected children under 2 years of age, including infected infants, are an extremely vulnerable group. This article assessed the findings of a recently published paper describing the outcome of 63 infants randomized to commence immediate or deferred HAART in a resource-poor setting and documented favorable short-term outcome in both groups, with correspondingly high adherence rates. The recent change in global treatment guidelines, recommending that all HIV-infected infants should be commenced on HAART soon after diagnosis, irrespective of their clinical status and/or immunological severity, is discussed in relation to the key findings of the article.