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Multicenter Study
. 2009 May;204(1):298-303.
doi: 10.1016/j.atherosclerosis.2008.08.016. Epub 2008 Aug 26.

Clinical and subclinical cardiovascular disease and kidney function decline in the elderly

Michael G Shlipak  1 , Ronit Katz, Bryan Kestenbaum, Linda F Fried, David Siscovick, Mark J Sarnak
Affiliations
Multicenter Study

Clinical and subclinical cardiovascular disease and kidney function decline in the elderly

Michael G Shlipak et al. Atherosclerosis. 2009 May.

Abstract

Objective: Kidney function decline in elderly persons may be the result of microvascular atherosclerosis. As a proxy for the renovascular system, we evaluated the association of clinical and subclinical cardiovascular disease (CVD) with kidney function decline.

Methods: This study included 4380 subjects from the Cardiovascular Health Study, a longitudinal, community-based cohort of persons aged >or=65 from 4 U.S. communities. Creatinine and cystatin C were measured at baseline, year 3, and year 7; eligible subjects had at least two measures. Creatinine-based estimated glomerular filtration rate (eGFR(creat)) was calculated using the MDRD equation. Rapid kidney function decline was defined as an annual eGFR loss >3 mL/min/1.73 m(2). Predictors of rapid kidney decline included prevalent and subclinical measures of CVD.

Results: Mean decline in eGFR(creat) was 0.4+/-2.6/year; 714 (16%) had rapid progression. In multivariate models adjusted for demographics, cardiovascular risk factors, and inflammation, prevalent stroke (OR, 95% CI: 1.55, 1.16-2.08) and heart failure (OR, 95% CI: 1.80, 1.40-2.31) were independent predictors of rapid kidney decline. Among persons without clinical CV, the subclinical disease measures ankle-arm index <0.9 (OR, 95% CI: 1.67, 1.25-2.24), common carotid intima-media thickness (>or=1.14 mm) (OR, 95% CI: 1.52, 1.12-2.06) and internal carotid intima-media thickness (>1.82 mm) (OR, 95% CI: 1.50, 1.12-2.02) had independent associations with rapid kidney function decline. Results were similar using cystatin C.

Conclusion: Clinical atherosclerosis and heart failure and subclinical measures of CVD have independent associations with kidney function decline progression in the elderly, suggesting an underlying role of renal atherosclerosis.

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Figures

Figure 1
Figure 1
Association of Clinical Cardiovascular Disease with Kidney Function Decline
Figure 2
Figure 2
Association of Subclinical Cardiovascular Disease Measures with Kidney Function Decline
See this image and copyright information in PMC

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