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. 2008 Nov;40(11):1282-4.
doi: 10.1038/ng.255. Epub 2008 Oct 12.

Male-pattern baldness susceptibility locus at 20p11

J Brent Richards  1 , Xin Yuan, Frank Geller, Dawn Waterworth, Veronique Bataille, Daniel Glass, Kijoung Song, Gerard Waeber, Peter Vollenweider, Katja K H Aben, Lambertus A Kiemeney, Bragi Walters, Nicole Soranzo, Unnur Thorsteinsdottir, Augustine Kong, Thorunn Rafnar, Panos Deloukas, Patrick Sulem, Hreinn Stefansson, Kari Stefansson, Tim D Spector, Vincent Mooser
Affiliations

Male-pattern baldness susceptibility locus at 20p11

J Brent Richards et al. Nat Genet. 2008 Nov.

Abstract

We conducted a genome-wide association study for androgenic alopecia in 1,125 men and identified a newly associated locus at chromosome 20p11.22, confirmed in three independent cohorts (n = 1,650; OR = 1.60, P = 1.1 x 10(-14) for rs1160312). The one man in seven who harbors risk alleles at both 20p11.22 and AR (encoding the androgen receptor) has a sevenfold-increased odds of androgenic alopecia (OR = 7.12, P = 3.7 x 10(-15)).

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Figures

Figure 1
Figure 1
Association between SNPs near chromosome 20p11.22 and androgenic alopecia. (a) −log (P value) measures for association between SNPs and chromosomal position. (b) Recombination hot spots (HapMap CEPH population, NCBI build 36). (c) Linkage disequilibrium in GOLD heat map Haploview 4.0 color scheme, CEPH population. The x axis represents genomic position in Mb (a) and in kb (b,c). All P values are derived from the CoLaus cohort, except that for the lead SNP, rs11603132, which is derived from the combined P value from the CoLaus, TwinsUK, Icelandic and Dutch cohorts.
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