Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Dec;32(12):2643-9.
doi: 10.1007/s00268-008-9758-7.

High postoperative interleukin-8 levels related to atrial fibrillation in patients undergoing coronary artery bypass surgery

Zhong-Kai Wu  1 , Jari Laurikka, Saila Vikman, Riina Nieminen, Eeva Moilanen, Matti R Tarkka
Affiliations

High postoperative interleukin-8 levels related to atrial fibrillation in patients undergoing coronary artery bypass surgery

Zhong-Kai Wu et al. World J Surg. 2008 Dec.

Abstract

Background: Atrial fibrillation (AF) is the most frequently encountered postoperative arrhythmic complication after coronary artery bypass graft (CABG). There is increasing evidence to support the influence of inflammation in the pathogenesis of AF. The aim of the present study was to investigate the relation of postoperative new AF and systemic inflammatory changes after CABG.

Methods: A total of 113 CABG patients were recruited in the present study. Holter data from 24-hour electrocardiography were collected from 1 day before the operation to postoperative day 2 (POD2). AF was registered as positive if any AF event occurred. Serum cytokine, including interleukin (IL)-6, IL-8, and IL-10 were analyzed before and after surgery.

Results: The overall incidences of postoperative AF and sustained AF were 36.3% and 31.9%, respectively. Patients with postoperative AF had longer respiratory treatment, intensive care unit treatment, and inotropic medication periods. Similar concentrations of serum IL-6 were found after surgery in patients with and without AF. The concentrations of serum IL-8 was significantly higher at 2 hours and on POD1 and POD2 in patients with postoperative AF. The concentration of serum IL-10 was significantly higher on POD1 in patients with postoperative AF.

Conclusions: Postoperative AF in CABG patients is associated with a more complicated postoperative outcome. Higher concentrations of serum IL-8 in CABG patients with postoperative AF suggested that an influence of inflammation in the pathogenesis postoperative AF after open heart surgery.

PubMed Disclaimer

References

    1. Eur Heart J. 2005 Oct;26(20):2083-92 - PubMed
    1. J Cardiothorac Vasc Anesth. 2006 Feb;20(1):51-6 - PubMed
    1. J Am Coll Cardiol. 2007 Nov 20;50(21):2021-8 - PubMed
    1. J Thorac Cardiovasc Surg. 2001 Apr;121(4):638-41 - PubMed
    1. Ann Thorac Surg. 2006 Jul;82(1):97-102 - PubMed

Publication types

LinkOut - more resources