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Review
. 2009 Mar 10;315(5):727-32.
doi: 10.1016/j.yexcr.2008.09.017. Epub 2008 Oct 1.

The insulin receptor substrate-1: a biomarker for cancer?

Renato Baserga  1
Affiliations
Review

The insulin receptor substrate-1: a biomarker for cancer?

Renato Baserga. Exp Cell Res. .

Abstract

This review focuses on IRS-1 and the evidence of its role in cell transformation. The literature strongly suggests that IRS-1 should be considered a biomaker for cancers susceptible to IGF-IR targeting. In addition, I would like to propose that IRS-1 may have a more general role in cancer, and could be considered as a protein having the opposite effect of tumor suppressors, a sort of anti-p53 molecule.

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