Therapeutic options to treat sulfur mustard poisoning--the road ahead
- PMID: 18852011
- DOI: 10.1016/j.tox.2008.09.012
Therapeutic options to treat sulfur mustard poisoning--the road ahead
Abstract
For the past 15 years the international research community has conducted a basic and applied research program aimed at identifying a medical countermeasure against chemical threat vesicant, or blistering, agents. The primary emphasis of this program has been the development of therapeutic protection against sulfur mustard and its cutaneous pathology-blister formation. In addition to the work on a medical countermeasures, significant research has been conducted on the development of topical skin protectants and medical strategies for wound healing. This review will focus on the pharmacological strategies investigated, novel therapeutic targets currently under investigation and therapeutic approaches being considered for transition to advanced development. Additionally, we will review the expansion of our understanding of the pathophysiological mechanisms of mustard injury that has come from this research. While great strides have been made through these investigations, the complexity of the mustard insult demands that further studies extend the inroads made and point the way toward better understanding of cellular and tissue disruptions caused by sulfur mustard.
Similar articles
-
Medical management of cutaneous sulfur mustard injuries.Toxicology. 2009 Sep 1;263(1):47-58. doi: 10.1016/j.tox.2008.07.067. Epub 2008 Aug 14. Toxicology. 2009. PMID: 18762227
-
Acute effects of sulfur mustard injury--Munich experiences.Toxicology. 2009 Sep 1;263(1):3-8. doi: 10.1016/j.tox.2009.04.060. Epub 2009 May 29. Toxicology. 2009. PMID: 19482056
-
Toxicology and pharmacology of the chemical warfare agent sulfur mustard.Pharmacol Rev. 1996 Jun;48(2):289-326. Pharmacol Rev. 1996. PMID: 8804107 Review.
-
Clinical picture of sulfur mustard poisoning.Toxicology. 2009 Sep 1;263(1):1. doi: 10.1016/j.tox.2009.04.038. Epub 2009 Apr 19. Toxicology. 2009. PMID: 19386280 No abstract available.
-
Molecular toxicology of sulfur mustard-induced cutaneous inflammation and blistering.Toxicology. 2009 Sep 1;263(1):12-9. doi: 10.1016/j.tox.2009.01.019. Epub 2009 Jan 23. Toxicology. 2009. PMID: 19651324 Review.
Cited by
-
Chemical warfare agents.J Pharm Bioallied Sci. 2010 Jul;2(3):166-78. doi: 10.4103/0975-7406.68498. J Pharm Bioallied Sci. 2010. PMID: 21829312 Free PMC article.
-
Mechanisms mediating the vesicant actions of sulfur mustard after cutaneous exposure.Toxicol Sci. 2010 Mar;114(1):5-19. doi: 10.1093/toxsci/kfp253. Epub 2009 Oct 15. Toxicol Sci. 2010. PMID: 19833738 Free PMC article. Review.
-
The Use of Hydrogel Dressings in Sulfur Mustard-Induced Skin and Ocular Wound Management.Biomedicines. 2023 Jun 2;11(6):1626. doi: 10.3390/biomedicines11061626. Biomedicines. 2023. PMID: 37371720 Free PMC article. Review.
-
Assessment of Beta-2 Microglobulin Gene Edited Airway Epithelial Stem Cells as a treatment for Sulfur Mustard Inhalation.Front Genome Ed. 2022 Feb 7;4:781531. doi: 10.3389/fgeed.2022.781531. eCollection 2022. Front Genome Ed. 2022. PMID: 35199100 Free PMC article.
-
Mustard vesicating agent-induced toxicity in the skin tissue and silibinin as a potential countermeasure.Ann N Y Acad Sci. 2016 Jun;1374(1):184-92. doi: 10.1111/nyas.13099. Epub 2016 Jun 21. Ann N Y Acad Sci. 2016. PMID: 27326543 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous