Alterations in the expression pattern of TCR zeta chain in T cells from patients with hematological diseases

Abstract

The TCR zeta chain, a component of the T cell receptor (TCR)/CD3 complex, plays a significant role in the assembly of the receptor complex and in connecting antigen recognition to the intracellular signal transduction apparatus. Recently, studies have demonstrated altered expression and function of this signal transduction molecule in T cells from patients with hematological diseases. In this review, current knowledge concerning the biological feature and function of TCR zeta protein, splice variant and mutation of TCR zeta chain gene and alteration of expression pattern in hematological diseases and the related mechanism are summarized.