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. 2008 Oct 16;4(4):308-10.
doi: 10.1016/j.chom.2008.09.003.

Beyond the big three: systematic analysis of virulence factors in Cryptococcus neoformans

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Free article

Beyond the big three: systematic analysis of virulence factors in Cryptococcus neoformans

James Kronstad et al. Cell Host Microbe. .
Free article

Abstract

The fungal pathogen Cryptococcus neoformans has three major virulence factors: growth at 37 degrees C, capsule synthesis, and melanin formation. Recently in Cell, Liu et al. (2008) employed signature tagged mutagenesis to systematically identify virulence genes. Remarkably, mutations in many of these genes did not influence the major virulence traits.

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