Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Oct;21(4):606-25.
doi: 10.1128/CMR.00013-08.

Candida parapsilosis, an emerging fungal pathogen

David Trofa  1 , Attila Gácser, Joshua D Nosanchuk
Affiliations
Review

Candida parapsilosis, an emerging fungal pathogen

David Trofa et al. Clin Microbiol Rev. 2008 Oct.

Abstract

Candida parapsilosis is an emerging major human pathogen that has dramatically increased in significance and prevalence over the past 2 decades, such that C. parapsilosis is now one of the leading causes of invasive candidal disease. Individuals at the highest risk for severe infection include neonates and patients in intensive care units. C. parapsilosis infections are especially associated with hyperalimentation solutions, prosthetic devices, and indwelling catheters, as well as the nosocomial spread of disease through the hands of health care workers. Factors involved in disease pathogenesis include the secretion of hydrolytic enzymes, adhesion to prosthetics, and biofilm formation. New molecular genetic tools are providing additional and much-needed information regarding C. parapsilosis virulence. The emerging information will provide a deeper understanding of C. parapsilosis pathogenesis and facilitate the development of new therapeutic approaches for treating C. parapsilosis infections.

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
Percentages of candidal bloodstream isolates from 1991 to the present, calculated from Tables 1 and 2 (total = 18,454). The group “other candidal species” includes C. lusitaniae, C. krusei, C. guilliermondii, C. dubliniensis, and C. rugosa.
See this image and copyright information in PMC

References

    1. Abruzzo, G. K., A. M. Flattery, C. J. Gill, L. Kong, J. G. Smith, V. B. Pikounis, J. M. Balkovec, A. F. Bouffard, J. F. Dropinski, H. Rosen, H. Kropp, and K. Bartizal. 1997. Evaluation of the echinocandin antifungal MK-0991 (L-743,872): efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis. Antimicrob. Agents Chemother. 41:2333-2338. - PMC - PubMed
    1. Abu-Elteen, K. H., A. M. Abdul Malek, and N. A. Abdul Wahid. 1997. Prevalence and susceptibility of vaginal yeast isolates in Jordan. Mycoses 40:179-185. - PubMed
    1. Adler-Shohet, F., H. Waskin, and J. M. Lieberman. 2001. Amphotericin B lipid complex for neonatal invasive candidiasis. Arch. Dis. Child Fetal Neonatal ed. 84:F131-F133. - PMC - PubMed
    1. Agatensi, L., F. Franchi, F. Mondello, R. L. Bevilacqua, T. Ceddia, F. De Bernardis, and A. Cassone. 1991. Vaginopathic and proteolytic Candida species in outpatients attending a gynaecology clinic. J. Clin. Pathol. 44:826-830. - PMC - PubMed
    1. Almirante, B., D. Rodriguez, M. Cuenca-Estrella, M. Almela, F. Sanchez, J. Ayats, C. Alonso-Tarres, J. L. Rodriguez-Tudela, and A. Pahissa. 2006. Epidemiology, risk factors, and prognosis of Candida parapsilosis bloodstream infections: case-control population-based surveillance study of patients in Barcelona, Spain, from 2002 to 2003. J. Clin. Microbiol. 44:1681-1685. - PMC - PubMed

Publication types

Substances