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. 2008 Oct 21;99(8):1216-20.
doi: 10.1038/sj.bjc.6604619.

Adjuvant hysterectomy for treatment of residual disease in patients with cervical cancer treated with radiation therapy

T Ota  1 , N Takeshima, T Tabata, K Hasumi, K Takizawa
Affiliations

Adjuvant hysterectomy for treatment of residual disease in patients with cervical cancer treated with radiation therapy

T Ota et al. Br J Cancer. .

Abstract

The objective of this retrospective study was to determine the efficacy of adjuvant hysterectomy for treatment of residual disease in cervical carcinoma treated with radiation therapy. Between 1971 and 1996, 1590 patients with carcinoma of the uterine cervix (stages I-IIIb) were treated with radiation therapy. Three months after completion of radiation therapy, the status of local control was investigated, and total abdominal hysterectomy was performed in cases in which central residual disease existed in the cervix. Of the 1590 patients, residual disease was identified in 162 patients. Among these patients, 35 showed an absence of distant metastasis or lateral parametrial invasion and underwent hysterectomy. The overall 5- and 10-year survival rates for these patients were 68.6 and 65.7%, respectively. There was no significant difference in survival between patients with squamous cell carcinoma and those with non-squamous cell carcinoma or between patients with stage I/II carcinoma and those with stage III carcinoma. With respect to treatment-related morbidity, five (14.3%) patients suffered grade III or IV complications after hysterectomy. Adjuvant hysterectomy is an effective addition to radiation therapy in the treatment of cervical cancer, even in patients with stage III disease and in those with non-squamous cell carcinoma.

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Figures

Figure 1
Figure 1
Incidence of local control in response to radiation therapy (complete response) and number of patients who underwent subsequent hysterectomy because of residual disease.
Figure 2
Figure 2
Disease-specific survival according to treatment methods and the presence or absence of distant metastasis for patients with cervical carcinoma. Hyst=Hysterectomy.
Figure 3
Figure 3
Disease-specific survival according to clinical stage for patients with cervical carcinoma.
Figure 4
Figure 4
Disease-specific survival according to histologic type for patients with cervical carcinoma.
Figure 5
Figure 5
Disease-specific survival according to tumour size for patients with cervical carcinoma.
See this image and copyright information in PMC

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