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. 2009 Apr;135(4):543-50.
doi: 10.1007/s00432-008-0486-z. Epub 2008 Oct 15.

Grade I chondrosarcoma of bone: the Münster experience

Arne Streitbürger  1 , Helmut Ahrens, Maurice Balke, Horst Buerger, Winfried Winkelmann, Georg Gosheger, Jendrik Hardes
Affiliations

Grade I chondrosarcoma of bone: the Münster experience

Arne Streitbürger et al. J Cancer Res Clin Oncol. 2009 Apr.

Abstract

The surgical treatment of low-grade chondrosarcoma is controversial and the clinical course is difficult to predict. The purpose of this retrospective study was to review the authors' experience with the surgical treatment of 80 patients with grade I chondrosarcoma. Intralesional resection margins increased the rate of local recurrence statistically significant (p < 0.001). However, there was no influence of the resection margins on the overall survival (p > 0.05) or on the rate of metastasis (p > 0.05). Conservative surgery for special indications with adjuvant use of PMMA (poly-methylmethacrylate) offers satisfying local tumour control rates in the long bones. However, after intralesional tumour resection of pelvic chondrosarcoma, four out of four patients developed a local recurrence, whereas no patient treated with wide resection margins received a local relapse, which has been statistically significant (p < 0.001). In conclusion, intralesional resection of a grade I chondrosarcoma has a higher overall risk of local recurrence but is not associated with a poorer survival. This procedure can be recommended for stage I A tumours of the long bones of the extremities. However, in pelvic lesions it should be avoided because of a 100% recurrence rate.

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Figures

Fig. 1
Fig. 1
Distribution of tumour site of primary/secondary chondrosarcoma (total number n = 80) and local recurrence (primary/secondary chondrosarcoma)
See this image and copyright information in PMC

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