Rh(I)-catalyzed direct arylation of pyridines and quinolines
- PMID: 18855360
- PMCID: PMC2647742
- DOI: 10.1021/ja8059396
Rh(I)-catalyzed direct arylation of pyridines and quinolines
Abstract
A Rh(I)-catalyzed direct arylation of pyridine and quinoline heterocycles has been developed. The method provides rapid entry into an important class of substituted heterocycles employing inexpensive and readily available starting materials.
References
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For an analysis of heterocycles used in the preparation of drug candidates, see: Carey JS, Laffan D, Thomson C, Williams MT. Org Biomol Chem. 2006;4:2337.
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For a recent comprehensive review on direct arylation, see: Alberico D, Scott ME, Lautens M. Chem Rev. 2007;107:174.
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Excess Zn and catalytic Pd/C has been used to prepare 2-phenylpyridine in 52% yield from pyridine and phenyl chloride: Mukhopadhyay S, Rothenberg G, Gitis D, Baidossi M, Ponde DE, Sasson Y. Perkin Trans 2. 2000;9:1809.
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