doi: 10.1021/ja8059396.
Epub 2008 Oct 15.
Rh(I)-catalyzed direct arylation of pyridines and quinolines
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- PMID: 18855360
- PMCID: PMC2647742
- DOI: 10.1021/ja8059396
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Rh(I)-catalyzed direct arylation of pyridines and quinolines
J Am Chem Soc.
.
Abstract
A Rh(I)-catalyzed direct arylation of pyridine and quinoline heterocycles has been developed. The method provides rapid entry into an important class of substituted heterocycles employing inexpensive and readily available starting materials.
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References
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For an analysis of heterocycles used in the preparation of drug candidates, see: Carey JS, Laffan D, Thomson C, Williams MT. Org Biomol Chem. 2006;4:2337.
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For a recent comprehensive review on direct arylation, see: Alberico D, Scott ME, Lautens M. Chem Rev. 2007;107:174.
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Excess Zn and catalytic Pd/C has been used to prepare 2-phenylpyridine in 52% yield from pyridine and phenyl chloride: Mukhopadhyay S, Rothenberg G, Gitis D, Baidossi M, Ponde DE, Sasson Y. Perkin Trans 2. 2000;9:1809.
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