Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1948 Jun 1;87(6):489-501.
doi: 10.1084/jem.87.6.489.

The effect of nitrogen mustards on enzymes and tissue metabolism; the effect on enzymes

E S G BARRON, G R BARTLETT, Z B MILLER

The effect of nitrogen mustards on enzymes and tissue metabolism; the effect on enzymes

E S G BARRON et al. J Exp Med. .

Abstract

Nitrogen mustards are powerful inhibitors for choline oxidase, acetylcholine esterase, and choline acetylase, half-inhibition of the first enzyme being produced with concentrations around 1 x 10(-6)M; i.e., ten times less than the LD(50) values. Acetylcholine esterase and choline acetylase required higher concentrations. This inhibition seems to be due to the structural similarity of the ethylenimonium derivatives with choline and acetylcholine. A list of enzyme systems inhibited by nitrogen mustards is given.

PubMed Disclaimer

References

    1. Biochem J. 1927;21(5):1224-51 - PubMed