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. 1991 May-Jun;13(3):271-3.
doi: 10.1016/0892-0362(91)90072-5.

Prenatal nicotine exposure increased susceptibility to electroconvulsive shock (ECS) in adult rats

S A Britos  1 , O A Orsingher
Affiliations

Prenatal nicotine exposure increased susceptibility to electroconvulsive shock (ECS) in adult rats

S A Britos et al. Neurotoxicol Teratol. 1991 May-Jun.

Abstract

Female rats were treated during pregnancy (days 1-20) with nicotine (1 mg/kg SC, b.i.d.). When some aspects of maternal behavior and developmental parameters were recorded in mothers and pups, respectively, no changes were detected in the experimental group as compared with controls. However, adult offspring of nicotine-treated rats showed an increased susceptibility to ECS. These results demonstrate long-lasting deleterious effects induced by nicotine exposure during fetal life.

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