Review
[Minimal residual disease in leukemia]
[Article in
Japanese]
Affiliations
- PMID: 1888177
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Review
[Minimal residual disease in leukemia]
[Article in
Japanese]
Gan To Kagaku Ryoho.
1991 Sep.
Abstract
Recently, detection of the minimal residual disease (MRD) has become possible by polymerase chain reaction (PCR) using leukemia specific DNA or mRNA sequences originated from t(9; 22), t(1; 19) and t(14; 18) translocations, T cell receptor or immunoglobulin CDRIII. This method made possible to detect one leukemic cell out of 10(4)-10(5) cells, and the presence of MDR became clear during complete remission after chemotherapy or bone marrow transplantation. This suggests the usefulness of this method in the treatment of leukemia.
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