[Clinical experience and possibilities of rapid cytogenetic diagnosis of spontaneous abortions in the routine work load of a gynecology clinic]

Abstract

The practicability of rapid karyotyping of spontaneous abortions by short-term culturing of chorionic villi is demonstrated in a large clinical study. 836 samples from spontaneous abortions were karyotyped successfully. Pathological findings were found in a rate of 48.8% whereby 54% of these were observed in week 10-11 of pregnancy. With increasing maternal age, the frequency of abnormal karyotypes also increased. Most of the pathological findings were trisomies, followed by polyploidies and monosomies. Correlation between maternal age and the type of aberration was observed. Chromosomal normal abortions were dominated by 46,XX abortions. The advantage of the described method of rapid karyotyping is the fact, that by knowing the karyotype of an abortion, a suitable concept of therapy can be chosen. Furthermore, a quick diagnosis has a positive effect on the psychological state of a patient, following a spontaneous abortion.