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. 1948 Apr 1;87(4):275-82.
doi: 10.1084/jem.87.4.275.

Chemical studies in host-virus interactions; some additional methods of determining nutritional requirements for virus multiplication

S S COHEN, C B FOWLER

Chemical studies in host-virus interactions; some additional methods of determining nutritional requirements for virus multiplication

S S COHEN et al. J Exp Med. .

Abstract

Omission of a single constituent from a chemically defined medium approximating the virus growth-promoting properties of broth affects virus production in infected bacteria. This may be estimated by the one-step growth technique and the course of desoxyribose nucleic acid synthesis. Nine amino acids and one purine have been shown to be important by these tests. A combination of all constituents observed to be important by the single supplement and single omission techniques has approximated the virus growth-promoting properties of broth. Certain anomalous results have been commented upon.

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References

    1. J Exp Med. 1948 Apr 1;87(4):259-74 - PubMed
    1. J Exp Med. 1946 Oct 31;84(5):511-23 - PubMed
    1. J Exp Med. 1947 May 31;85(6):771-84 - PubMed