Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1948 Feb 1;87(2):157-62.
doi: 10.1084/jem.87.2.157.

The influence of available fluid on the production of experimental hemoglobinuric nephrosis in rabbits

J J LALICH

The influence of available fluid on the production of experimental hemoglobinuric nephrosis in rabbits

J J LALICH. J Exp Med. .

Abstract

The importance of previous dehydration on the production of hemoglobinuric nephrosis is substantiated. Hemoglobinuric nephrosis regularly occurred in rabbits 3 to 16 days following the injections of hemoglobin. Five of 15 animals died of fatal hemoglobinuric nephrosis; the combined kidney weight in these exceeded the weight of the kidneys of control rabbits and of those which survived. Additional observations, not previously made, are focal necrosis of the liver and pulmonary edema in some of the rabbits which died. A relationship was evident between the quantity of available fluid and the severity of the hemoglobinuric nephrosis which developed after injections of hemoglobin.

PubMed Disclaimer

References

    1. J Exp Med. 1947 Jul 31;86(2):153-8 - PubMed
    1. J Clin Invest. 1942 Nov;21(6):787-94 - PubMed