Review
doi: 10.1016/0968-0004(91)90092-a.
Semi-synthetic approaches to novel penicillins
- PMID: 1891804
- DOI: 10.1016/0968-0004(91)90092-a
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Review
Semi-synthetic approaches to novel penicillins
Trends Biochem Sci.
1991 Jun.
Abstract
The first part of this account of the discovery of penicillin, published in last month's issue of TIBS, concluded with the detection of 6-beta-amino-penicillanic acid (6-APA), the nucleus of the penicillin structure. The exploitation of 6-APA led to the preparation of a range of clinically important semi-synthetic penicillins, which is described in this article.
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