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Review
. 1991 Apr;13(2):179-83.

HTLV-I neurotropism. In vitro studies

B Macchi  1 , B Caronti, F Gremo, S Torelli, E Bonmassar, G M Lauro
Affiliations
  • PMID: 1891983
Review

HTLV-I neurotropism. In vitro studies

B Macchi et al. Acta Neurol (Napoli). 1991 Apr.

Abstract

The human T cell leukemia lymphoma virus (HTLV-I) has been recently associated to neurological disorders. In order to investigate the interaction between this virus and the central nervous system, cells of neuroectodermic origin have been exposed to HTLV-I through an experimental in vitro model. The results revealed the presence of HTLV-I virus core protein p19 inside glial cells, after a short time exposure to a chronically infected donor cell line. This suggests a possible role of a lymphotropic retrovirus in neurological diseases.

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