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Review
. 1991;22(2):105-15.
doi: 10.1111/j.1365-2052.1991.tb00652.x.

Genetic mapping by single sperm typing

N Arnheim  1 , H Li, X Cui
Affiliations
Review

Genetic mapping by single sperm typing

N Arnheim et al. Anim Genet. 1991.

Abstract

The polymerase chain reaction makes it possible to analyse DNA sequences in a single cell and has led to a new approach for constructing genetic maps. We describe a procedure called 'sperm typing' which can accurately classify individual meiotic products as recombinant of non-recombinant. This permits the linkage relationships among DNA polymorphisms to be determined without pedigree analysis.

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