Cell growth control: mTOR takes on fat
- PMID: 18922461
- DOI: 10.1016/j.molcel.2008.09.006
Cell growth control: mTOR takes on fat
Abstract
In a recent issue of Cell Metabolism, Porstmann et al. (2008) demonstrate that fatty acid biosynthesis, under the transcriptional control of SREBP1, is regulated by the rapamycin-sensitive mTOR signaling network, thus expanding the scope of biosynthetic processes integrated by mTOR.
Comment on
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SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.Cell Metab. 2008 Sep;8(3):224-36. doi: 10.1016/j.cmet.2008.07.007. Cell Metab. 2008. PMID: 18762023 Free PMC article.
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