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. 2008 Oct;70(8):845-9.
doi: 10.1097/PSY.0b013e318187d05e.

Dietary restraint and telomere length in pre- and postmenopausal women

Amy Kiefer  1 , Jue Lin, Elizabeth Blackburn, Elissa Epel
Affiliations

Dietary restraint and telomere length in pre- and postmenopausal women

Amy Kiefer et al. Psychosom Med. 2008 Oct.

Abstract

Background: Leukocyte telomere shortening can serve as a biomarker of aging, as telomere length (TL) can decline with age and shortening is positively associated with morbidity and mortality. It is therefore important to identify psychological and behavioral factors linked to accelerated telomere shortening. Stress and poorer metabolic health (greater adiposity, insulin resistance, and cortisol) correlate with shorter telomeres. Self-reported dietary restraint (DR), defined as chronic preoccupation with weight and attempts at restricting food intake, is linked to greater perceived stress, cortisol, and weight gain, when assessed in community studies (versus in weight loss programs).

Objective: To test for an association between DR and TL in healthy women across a range of ages.

Methods: We examined whether DR is linked to TL in two samples, one of premenopausal women (aged 20-50 years;N = 36) and one of postmenopausal women (aged 53-69 years; N = 20).

Results: In both samples, higher levels of DR were associated with shorter leukocyte TL, independent of body mass index, smoking, and age.

Conclusions: Chronic DR, as assessed by self-report (i.e. not caloric restriction), may be a risk factor for premature telomere shortening. Potential mechanisms are discussed.

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Figures

Figure 1
Figure 1
Scatter plot of dietary restraint and telomere length for Premenopausal women.
Figure 2
Figure 2
Scatter plot of dietary restraint and telomere length for Postmenopausal women.
See this image and copyright information in PMC

References

    1. Rozin P, Fischler C, Imada S, Sarubin A, Wrzesniewski A. Attitudes to food and the role of food in life in the U.S.A., Japan, Flemish Belgium and France: possible implications for the diet-health debate. Appetite. 1999;33(2):163–180. - PubMed
    1. Beiseigel JM, Nickols-Richardson SM. Cognitive eating restraint scores are associated with body fatness but not with other measures of dieting in women. Appetite. 2004;43(1):47–53. - PubMed
    1. Stice E, Fisher M, Lowe MR. Are dietary restraint scales valid measures of acute dietary restriction? Unobtrusive observational data suggest not. Psychol Assess. 2004;16(1):51–59. - PubMed
    1. Stice E, Cameron RP, Killen JD, Hayward C, Taylor CB. Naturalistic weight-reduction efforts prospectively predict growth in relative weight and onset of obesity among female adolescents. J Consult Clin Psychol. 1999;67(6):967–974. - PubMed
    1. Stice E, Hayward C, Cameron RP, Killen JD, Taylor CB. Body-image and eating disturbances predict onset of depression among female adolescents: a longitudinal study. J Abnorm Psychol. 2000;109(3):438–444. - PubMed

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