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Comment
. 2008 Oct 15;22(20):2750-4.
doi: 10.1101/gad.1735508.

About the importance of being desulfated

Richa Khatri  1 , Ernestina Schipani
Affiliations
Comment

About the importance of being desulfated

Richa Khatri et al. Genes Dev. .

Abstract

Sulfated proteoglycans have important structural and signaling functions in the growth plate. In the October 1, 2008, issue of Genes & Development, Settembre and colleagues (2645-2650) report that lack of SUMF1, a crucial enzyme in the activation of sulfatases, causes a severe chondrodysplasia by augmenting fibroblast growth factor signaling and by hampering the autophagic process, which the investigators show is constitutively on in chondrocytes. The findings highlight the essential role of desulfation in cartilage biology and organogenesis.

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Figures

Figure 1.
Figure 1.
A hematoxylin and eosin (H&E)-stained histological section of a newborn proximal tibia growth plate is shown. Superimposed is a model of the role of autophagy in growth plate chondrocyte survival, particularly in the hypoxic region. According to this model, an impairment of the autophagic process, as occurs secondary to lack of SUMF1, would lead to cell death.
See this image and copyright information in PMC

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References

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