Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Mar;129(3):629-34.
doi: 10.1038/jid.2008.297. Epub 2008 Oct 16.

Further genetic evidence for three psoriasis-risk genes: ADAM33, CDKAL1, and PTPN22

Yonghong Li  1 , Wilson Liao, Monica Chang, Steven J Schrodi, Nam Bui, Joseph J Catanese, Annie Poon, Nori Matsunami, Kristina P Callis-Duffin, Mark F Leppert, Anne M Bowcock, Pui-Yan Kwok, Gerald G Krueger, Ann B Begovich
Affiliations

Further genetic evidence for three psoriasis-risk genes: ADAM33, CDKAL1, and PTPN22

Yonghong Li et al. J Invest Dermatol. 2009 Mar.

Abstract

Predisposition to psoriasis is known to be affected by genetic variation in HLA-C, IL12B, and IL23R, and although other psoriasis-associated variants have been identified, incontrovertible statistical evidence for these markers has not yet been obtained. To help resolve this issue, we tested 15 single-nucleotide polymorphisms (SNPs) from 7 putative psoriasis-risk genes in 1,448 psoriasis patients and 1,385 control subjects; 3 SNPs, rs597980 in ADAM33, rs6908425 in CDKAL1 and rs3789604 in PTPN22, were significant with the same risk allele as in prior reports (one-sided P<0.05, false discovery rate<0.15). These three markers were tested in a fourth sample set (599 cases and 299 controls); one marker, rs597980, replicated (one-sided P<0.05) and the other two had odds ratios with the same directionality as in the original sample sets. Mantel-Haenszel meta-analyses of all available case-control data, including those published by other groups, showed that these three markers were highly significant (rs597980: P=0.0057 (2,025 cases and 1,597 controls), rs6908425: P=1.57 x 10(-5) (3,206 cases and 4,529 controls), and rs3789604: P=3.45 x 10(-5) (2,823 cases and 4,066 controls)). These data increase the likelihood that ADAM33, CDKAL1, and PTPN22 are true psoriasis-risk genes.

PubMed Disclaimer

Conflict of interest statement

CONFLICT OF INTEREST

Authors with affiliations to Celera have personal financial interest in the company.

References

    1. Barrett J, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, et al. Genome-wide association defines more than thirty distinct susceptibility loci for Crohn’s disease. Nat Genet. 2008;40:955–62. - PMC - PubMed
    1. Begovich AB, Carlton VE, Honigberg LA, Schrodi SJ, Chokkalingam AP, Alexander HC, et al. A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am J Hum Genet. 2004;75:330–7. - PMC - PubMed
    1. Benjamini Y, Hockberg Y. Controlling the false discovery rate: a new and powerful approach to multiple testing. J R Stat Soc Ser B. 1995;57:1289–300.
    1. Bottini N, Musumeci L, Alonso A, Rahmouni S, Nika K, Rostamkhani M, et al. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat Genet. 2004;36:337–8. - PubMed
    1. Bowcock AM, Cookson WO. The genetics of psoriasis, psoriatic arthritis and atopic dermatitis. Hum Mol Genet. 2004;13(Spec No 1):R43–55. - PubMed

Publication types