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Case Reports
. 2007 Mar;18(2):149-50.
doi: 10.1155/2007/768734.

Treatment of candiduria with micafungin: A case series

Danny Lagrotteria  1 , Coleman Rotstein, Christine H Lee
Affiliations
Case Reports

Treatment of candiduria with micafungin: A case series

Danny Lagrotteria et al. Can J Infect Dis Med Microbiol. 2007 Mar.

Abstract
in English, French

There has been a gradual increase in the incidence of non-Candida albicans-related nosocomial infections. Candida glabrata urinary tract infections have increased in frequency, and treating these infections can be difficult because the organism may be resistant to fluconazole. A newer antifungal agent, micafungin, which belongs in the class of echinocandins, provides an alternative and effective therapy against C glabrata. The present report describes three cases of C glabrata-associated urinary tract infections successfully treated with micafungin. To the authors' knowledge, this is the first report of successful treatment of C glabrata and azole-resistant C albicans-associated urinary tract infection with an echinocandin.

Il y a eu une augmentation graduelle des infections nosocomiales à d’autres germes que Candida albicans au fil du temps. La fréquence des infections urinaires à Candida glabrata est plus élevée qu’avant et il peut être difficile de traiter ces infections parce que le micro-organisme en cause peut se montrer résistant au fluconazole. Un nouveau médicament antifongique, la micafungine, qui appartient à la classe des échinocandines, offre un traitement de rechange efficace contre C glabrata. Le présent rapport fait état de trois cas d’infection urinaire à C glabrata, traités avec succès à la micafungine. D’après les auteurs, il s’agirait là du premier rapport de traitement réussi d’infections urinaires à C glabrata et à C albicans résistant aux azoles, à l’aide d’une échinocandine.

Keywords: Candiduria; Echinocandins.

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