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Comparative Study
. 1991 Jun;40(6):643-6.

[Tumor necrosis factor in sputa of patients with bronchial asthma on exacerbation]

[Article in Japanese]
F Taki  1 , Y Kondoh, K Matsumoto, K Takagi, T Satake, H Taniguchi, M Matsuzaki
Affiliations
  • PMID: 1892447
Comparative Study

[Tumor necrosis factor in sputa of patients with bronchial asthma on exacerbation]

[Article in Japanese]
F Taki et al. Arerugi. 1991 Jun.

Abstract

TNF is a cytokine recently implicated as an important inflammatory mediator. TNF concentrations in sputa from 13 patients with bronchial asthma on exacerbation and 12 patients with chronic obstructive pulmonary disease were measured. After sonication, the sputa were centrifuged. The supernatants were assayed for the presence of TNF by use of an enzyme-linked immunosorbent assay. TNF was detected in all patients with bronchial asthma (1783 +/- 420 pg/ml), while low values of TNF were detected in only 5 of the 12 COPD patients. It is suggested that TNF is involved in airway inflammation in bronchial asthma.

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