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Review
. 2008;213(9-10):701-13.
doi: 10.1016/j.imbio.2008.07.008. Epub 2008 Sep 7.

From expression to signaling: roles of TREM-1 and TREM-2 in innate immunity and bacterial infection

Omar Sharif  1 , Sylvia Knapp
Affiliations
Review

From expression to signaling: roles of TREM-1 and TREM-2 in innate immunity and bacterial infection

Omar Sharif et al. Immunobiology. 2008.

Abstract

Triggering receptor expressed on myeloid cells (TREM) proteins play important roles in innate and adaptive immunity. Since the discovery of TREM-1 and TREM-2 in 2000, the field has exploded over the past 8 years and currently TREM-1 is thought of as an amplifier of the immune response, while TREM-2 is believed to be a negative regulator. Here, we discuss the current state of the literature on TREMs, with a focus on TREM-1 and TREM-2 and their expression, signaling in mononuclear phagocytes and roles in innate immunity and bacterial infection.

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