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Controlled Clinical Trial
. 2008 Oct;21(10):1109-15.
doi: 10.1016/j.echo.2008.07.018.

Regional diastolic contour abnormalities during contrast stress echocardiography: improved detection of coronary artery disease

Sonja Cukon-Buttignoni  1 , Sahar S Abdelmoneim, Jo-Ellen Ehrsam, Marion E Barnes, Mary E Hagen, Lori A Carlson, Sabino Iliceto, Sharon L Mulvagh
Affiliations
Controlled Clinical Trial

Regional diastolic contour abnormalities during contrast stress echocardiography: improved detection of coronary artery disease

Sonja Cukon-Buttignoni et al. J Am Soc Echocardiogr. 2008 Oct.

Abstract

Background: Use of contrast improves detection of systolic regional wall motion abnormalities (RWMAs) during stress echocardiography. We evaluated regional diastolic contour abnormalities (RDCAs) that were associated with coronary artery disease (CAD).

Methods: From August of 2003 to September of 2004, we evaluated 89 patients who underwent contrast stress echocardiography (CSE) and coronary angiography within a 3-month period ("invasive" group) and 17 patients with lower CAD risk who underwent CSE only ("reference" group).

Results: RDCAs were present in 73 patients in the invasive group and were associated with higher Framingham risk scores (relative risk, 3.6; 95% confidence interval, 1.9-6.6). RDCAs were present in 1 patient in the reference group. When combined with RWMA, RDCA improved sensitivity of CSE from 78% to 97% and specificity from 26% to 59% (diagnostic threshold for CAD was 70% stenosis).

Conclusion: RDCAs were a novel observation associated with higher CAD risk and improved the diagnostic accuracy of CSE.

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