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Randomized Controlled Trial
. 2008 Oct;199(4):433.e1-8.
doi: 10.1016/j.ajog.2008.07.011.

Antioxidant supplementation and premature rupture of the membranes: a planned secondary analysis

Joseph A Spinnato 2nd  1 , Salvio Freire, Joao Luiz Pinto e Silva, Marilza Vieira Cunha Rudge, Sérgio Martins-Costa, Matthew A Koch, Norman Goco, Cleide de Barros Santos, Jose Guilherme Cecatti, Roberto Costa, José Geraldo Ramos, Nancy Moss, Baha M Sibai
Affiliations
Randomized Controlled Trial

Antioxidant supplementation and premature rupture of the membranes: a planned secondary analysis

Joseph A Spinnato 2nd et al. Am J Obstet Gynecol. 2008 Oct.

Abstract

Objective: The purpose of this study was to determine if antioxidant supplementation during pregnancy reduces the incidence of premature rupture of the membranes (PROM).

Study design: A placebo-controlled, double-blind trial was conducted. PROM and preterm PROM (PPROM) were planned secondary outcomes of the trial. Women between 12(0/7) and 19(6/7) weeks of gestation and diagnosed to have chronic hypertension or a prior history of preeclampsia were randomized to daily treatment with both vitamin C (1000 mg) and E (400 IU) or placebo.

Results: Outcome data for PROM were available for 697 of 739 patients. The rates of PROM (37/349 [10.6%] vs 19/348 [5.5%]; adjusted risk ratio [RR] 1.89 [95.42% CI, 1.11-3.23]; P = .015), and PPROM (16/349 [4.6%] vs 6/348 [1.7%]; RR 2.68 [1.07-6.71]; P = .025) were increased in the antioxidant group.

Conclusion: Contrary to expectations, vitamins C and E supplementation in this dose combination may be associated with an increased risk of PROM and PPROM.

Trial registration: ClinicalTrials.gov NCT00097110.

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Figures

Figure 1
Figure 1
Enrollment Flow Chart
See this image and copyright information in PMC

References

    1. Premature rupture of the membranes. ACOG Practice Bulletin. Number 80. 2007 April
    1. Woods JR, Jr, Plessinger MA, Miller RK. Vitamins C and E: missing links in preventing preterm premature rupture of membranes? Am J Obstet Gynecol. 2001 Jul;185(1):5–10. - PubMed
    1. Woods JR., Jr Reactive oxygen species and preterm premature rupture of membranes-a review. Placenta. 2001 Apr;22 Suppl A:S38–S44. - PubMed
    1. Spinnato JA, Freire S, Pinto e Silva JL, Cunha Rudge M, Martins-Costa S, et al. Antioxidant Therapy to Prevent Preeclampsia: A Randomized Controlled Trial. Obstet Gynecol. 2007 Dec;110(6):1311–1318. - PubMed
    1. Alexander GR, Himes JH, Kaufman RB, Mor J, Kogan M. A United States national reference for fetal growth. Obstet Gynecol. 1996 Feb;87(2):163–168. - PubMed

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