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Comparative Study
. 2009 Nov;92(5):1674-8.
doi: 10.1016/j.fertnstert.2008.08.110. Epub 2008 Oct 18.

Variations in serum müllerian inhibiting substance between white, black, and Hispanic women

David B Seifer  1 , Elizabeth T Golub, Geralyn Lambert-Messerlian, Lorie Benning, Kathryn Anastos, D Heather Watts, Mardge H Cohen, Roksana Karim, Mary A Young, Howard Minkoff, Ruth M Greenblatt
Affiliations
Comparative Study

Variations in serum müllerian inhibiting substance between white, black, and Hispanic women

David B Seifer et al. Fertil Steril. 2009 Nov.

Abstract

Objective: To compare serum müllerian inhibiting substance (MIS) levels between white, black, and Hispanic women to determine whether ovarian aging occurs at a different time course for women of different racial groups.

Design: Longitudinal study of serum MIS levels in women of different race and ethnicity over two different time points.

Setting: Women's Interagency HIV Study, a multicenter prospective cohort study.

Patient(s): Serum samples obtained from 809 participants (122 white, 462 black, and 225 Hispanic women).

Intervention(s): Comparison of serum MIS between women of different race and ethnicity at two time points (median age 37.5 years and 43.3 years).

Main outcome measure(s): Variation in MIS by race and ethnicity over time, controlling for age, body mass index, HIV status, and smoking.

Result(s): Compared with white women, average MIS values were lower among black (25.2% lower) and Hispanic (24.6% lower) women, adjusting for age, body mass index, smoking, and HIV status.

Conclusion(s): There is an independent effect of race and ethnicity on the age-related decline in MIS over time.

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Figures

FIG. 1
FIG. 1
Standard boxplots of Müllerian Inhibiting Substance (MIS; top panel) showing the median (white center line), interquartile range (IQR; black box), 1.5 times the IQR (whiskers), and values greater than 1.5 times the IQR (solid detached lines) and percentage of undetectable values (MIS<0.1 ng/mL; bottom panel) by racial category and visit.
See this image and copyright information in PMC

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