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. 2009 Feb;17(2):211-5.
doi: 10.1007/s00520-008-0517-y. Epub 2008 Oct 18.

Observational Aranesp Survey to Investigate the Q3W Schedule (OASIS): a prospective observational study of treatment of chemotherapy-induced anaemia with every 3 weeks darbepoetin alfa

K Pat  1 , B Anrys, D Verhulst, F Van Aelst, K Van Eygen, D Galdermans, D Verhoeven, M Polus, K Segers, M P Derde, I Wauters, J Vansteenkiste
Affiliations

Observational Aranesp Survey to Investigate the Q3W Schedule (OASIS): a prospective observational study of treatment of chemotherapy-induced anaemia with every 3 weeks darbepoetin alfa

K Pat et al. Support Care Cancer. 2009 Feb.

Abstract

Introduction: This prospective observational study examined the adherence to published European guidelines on erythropoiesis-stimulating agents (ESAs) and the pattern of use and effect of darbepoetin alfa (DA) 500 microg once every 3 weeks (Q3W) for the treatment of chemotherapy-induced anaemia (CIA).

Materials and methods: A total of 293 patients were included (263 solid tumour, 30 haematologic malignancy). Their mean age was 63 years, 51% were male, 57% had platinum-based chemotherapy. DA was started at a haemoglobin (Hb) level between 9 and 11 g/dL in 82% of patients.

Results and discussion: In an analysis correcting for transfusions, 55% of patients achieved > or =2 g/dL increase in Hb, and a Hb level of >11 g/dL was reached in 81%. Transfusion rate was 27%. Most patients (70%) were treated in a Q3W chemotherapy, and planned synchronisation of chemotherapy and Q3W DA could be maintained in 76%.

Conclusion: Adherence to European guidelines for DA treatment was good, and Q3W DA treatment was in synchronisation with Q3W chemotherapy in the majority of the patients, thereby reproducing the findings of a recent phase III study.

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References

    1. Eur J Cancer. 2007 Jan;43(2):258-70 - PubMed
    1. Expert Rev Anticancer Ther. 2007 Oct;7(10):1347-55 - PubMed
    1. J Natl Cancer Inst. 2002 Aug 21;94(16):1211-20 - PubMed
    1. Eur J Cancer. 2005 May;41(8):1140-9 - PubMed
    1. J Natl Cancer Inst. 2005 Apr 6;97(7):489-98 - PubMed

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