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. 2008 Nov;138(11):2284-8.
doi: 10.3945/jn.108.096347.

Hepcidin regulation of iron transport

James F Collins  1 , Marianne Wessling-Resnick, Mitchell D Knutson
Affiliations
Free PMC article

Hepcidin regulation of iron transport

James F Collins et al. J Nutr. 2008 Nov.
Free PMC article

Abstract

The discovery of hepcidin as a key regulator of iron homeostasis has advanced our current knowledge of this field. Liver-derived hepcidin peptide is secreted in response to iron and inflammation and interacts with the iron export protein ferroportin. This review summarizes recent advances discussed at the Symposium. A particular focus is on molecular interactions between hepcidin and ferroportin, the regulation of hepcidin expression by iron and inflammation, and emerging methods to measure serum hepcidin in human populations.

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