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Comparative Study
. 2008 Oct 21;71(17):1355-60.
doi: 10.1212/01.wnl.0000327672.04729.8c.

Primary CNS lymphoma with intraocular involvement: International PCNSL Collaborative Group Report

S A Grimm  1 , C A McCannel, A M P Omuro, A J M Ferreri, J-Y Blay, E A Neuwelt, T Siegal, T Batchelor, K Jahnke, T N Shenkier, A J Hall, F Graus, U Herrlinger, D Schiff, J Raizer, J Rubenstein, N Laperriere, E Thiel, N Doolittle, F M Iwamoto, L E Abrey
Affiliations
Comparative Study

Primary CNS lymphoma with intraocular involvement: International PCNSL Collaborative Group Report

S A Grimm et al. Neurology. .

Abstract

Objective: To describe the demographics, diagnostic details, therapeutic management, and outcome in patients with primary CNS lymphoma (PCNSL) with ocular involvement.

Methods: A retrospective study of 221 patients was assembled from 16 centers in seven countries. Only HIV-negative, immunocompetent patients with brain and ocular lymphoma were included; none had systemic lymphoma.

Results: Median age at diagnosis was 60. Fifty-seven percent were women. Median Eastern Cooperative Oncology Group performance status was 2. Ocular disturbance and behavioral/cognitive changes were the most common presenting symptoms. Diagnosis of lymphoma was made by brain biopsy (147), vitrectomy (65), or CSF cytology (11). Diagnosis of intraocular lymphoma was made by vitrectomy/choroidal/retinal biopsy (90) or clinical ophthalmic examination (141). CSF cytology was positive in 23%. Treatment information was available for 176 patients. A total of 102 received dedicated ocular therapy (ocular radiotherapy 79, intravitreal methotrexate 22, and both 1) in addition to treatment for their brain lymphoma. Sixty-nine percent progressed at a median of 13 months; sites of progression included brain 52%, eyes 19%, brain and eyes 12%, and systemic 2%. Patients treated with local ocular therapy did not have a statistically significant decreased risk of failing in the eyes (p = 0.7). Median progression free survival and overall survival for the entire cohort were 18 and 31 months.

Conclusion: This is the largest reported series of primary CNS lymphoma (PCNSL) with intraocular involvement. Progression free and overall survival was similar to that reported with PCNSL. Dedicated ocular therapy improved disease control but did not affect overall survival.

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Figures

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Figure 1 Kaplan–Meier curve showing progression free (dashed line) and overall survival (solid line) for all 221 patients with primary CNS lymphoma with intraocular involvement
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Figure 2 Kaplan–Meier curve showing progression free survival for patients treated with (dashed line) and without (solid line) dedicated ocular therapy in addition to treatment for their brain disease
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Figure 3 Kaplan–Meier curve showing overall survival for patients treated with (dashed line) and without (solid line) dedicated ocular therapy in addition to treatment for their brain disease
See this image and copyright information in PMC

References

    1. Choi JY, Kafkala C, Foster CS. Primary intraocular lymphoma: a review. Semin Ophthalmol 2006;21:125–133. - PubMed
    1. Nussenblatt RB, Chan CC, Wilson WH, Hochman J, Gottesman M. International Central Nervous System and Ocular Lymphoma Workshop: recommendations for the future. Ocul Immunol Inflamm 2006;14:139–144. - PMC - PubMed
    1. Grimm SA, Pulido JS, Jahnke K, et al. Primary intraocular lymphoma: an International Primary Central Nervous System Lymphoma Collaborative Group Report. Ann Oncol 2007;18:1851–1855. - PubMed
    1. Kaplan E, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457–481.
    1. Chan CC, Wallace DJ. Intraocular lymphoma: update on diagnosis and management. Cancer Control 2004; 11:285–295. - PMC - PubMed

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