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. 2008 Oct;101(4):413-8.
doi: 10.1016/S1081-1206(10)60319-5.

Correlation between airway inflammation and loss of deep-inhalation bronchoprotection in asthma

Nathan D Allen  1 , Beth E Davis, Donald W Cockcroft
Affiliations

Correlation between airway inflammation and loss of deep-inhalation bronchoprotection in asthma

Nathan D Allen et al. Ann Allergy Asthma Immunol. 2008 Oct.

Abstract

Background: One of the characteristic features of the hyperresponsive airway smooth muscle in asthma is the loss of deep-inhalation bronchoprotection and bronchodilation. The airway of individuals with asthma is also characterized by inflammation.

Objective: To evaluate whether the loss of deep-inhalation bronchoprotection is correlated with the degree of inflammation in the asthmatic airway.

Methods: Eighteen study participants performed 2 methacholine challenges (identical doses), 1 with deep inhalations and 1 without, separated by at least 24 hours. Airway inflammation was evaluated by measurement of fraction of exhaled nitric oxide (FE(NO)) and induced sputum eosinophils.

Results: A significant negative correlation was found between the degree of deep-inhalation bronchoprotection and airway inflammation when measured by FE(NO) (P = .02, r = .54, n = 18) and by percentage of eosinophils (P = .002, r = .76, n = 12). A significant positive correlation was also found between the FE(NO) and percentage of eosinophils (P = .009, r = .68, n = 12).

Conclusions: Deep-inhalation bronchoprotection was significantly impaired in individuals with greater airway inflammation. This finding suggests that therapy directed at decreasing airway inflammation may promote the recovery of normal deep-inhalation bronchoprotection.

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