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. 1991 Sep;56(3):465-8.
doi: 10.1016/s0015-0282(16)54541-5.

Cervical mucus score and in vitro sperm mucus interaction in spontaneous and clomiphene citrate cycles

J M Randall  1 , A Templeton
Affiliations
Free article

Cervical mucus score and in vitro sperm mucus interaction in spontaneous and clomiphene citrate cycles

J M Randall et al. Fertil Steril. 1991 Sep.
Free article

Abstract

Objective: Assessment of the effects of clomiphene citrate (CC) on cervical mucus score and in vitro sperm mucus interaction.

Design: Prospective study of cervical mucus score and in vitro sperm mucus interaction in a spontaneous cycle followed by a CC cycle to compare paired data.

Setting: Tertiary institutional infertility clinic.

Patients, participants: Twenty-two couples with primary unexplained infertility were studied in both cycles.

Interventions: Clomiphene citrate (150 mg) on days 5 to 9 in CC cycles.

Main outcome measures: Cervical mucus score and sperm-mucus penetration test score.

Results: Mean cervical mucus score in spontaneous cycles was 9.3 (95% confidence interval [CI] 8.4 to 10.2) and in CC cycles 5.6 (95% CI 4.6 to 6.6), P less than 0.0001. Sperm-mucus penetration test score in spontaneous cycles was 11.4 (95% CI 7.6 to 15.2) and in CC cycles 3.9 (95% CI 1.17 to 6.63), P less than 0.01.

Conclusions: Clomiphene citrate has an adverse effect on both cervical mucus score and sperm-mucus penetration.

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