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Review
. 2008 Nov;28(4):765-78, viii.
doi: 10.1016/j.iac.2008.06.002.

Intravenous immunoglobulins: evolution of commercial IVIG preparations

John A Hooper  1
Affiliations
Review

Intravenous immunoglobulins: evolution of commercial IVIG preparations

John A Hooper. Immunol Allergy Clin North Am. 2008 Nov.

Abstract

Since its first use in 1952, human immunoglobulin has been used to treat people who have inherited antibody deficiencies. This article summarizes IVIG clinical development in primary immunodeficient patients and manufacturing improvements introduced over time. Manufacturing improvements include purification procedures that have reduced the incidence of adverse events and improved clinical efficacy, as well as virus inactivation and removal steps that have increased safety from blood-borne infections. Current manufacturing procedures, IVIG production trends, and recent clinical trial results are also reviewed.

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References

    1. Bruton O.C. Agammaglobulinema. Pediatrics. 1952;9:722–727. - PubMed
    1. Cohn E.J., Strong L.E., Hughes W.L., Jr. Preparation and properties of serum and plasma proteins III: a system for the separation into fractions of the protein and lipoprotein components of biological tissues and fluids. J Am Chem Soc. 1946;68:459–475. - PubMed
    1. Oncley J.L., Melin M., Richert D.A. The separation of the antibodies, isoagglutinins, prothrombin, plasminogen and beta-lipoprotein into subfractions of human plasma. J Am Chem Soc. 1949;71:541–550. - PubMed
    1. Barandun S., Kistler P., Jeunet F. Intravenous administration of human gamma globulin. Vox Sang. 1962;7:157–174. - PubMed
    1. Aronson D.L., Finlayson J.S. Historical and future therapeutic plasma derivatives (Epilogue) Semin Thromb Hemost. 1980;VI:1231–1239.

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