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Review
. 2008 Nov;28(4):833-49, ix.
doi: 10.1016/j.iac.2008.07.001.

Immunoglobulin replacement therapy in children

Maria Garcia-Lloret  1 , Sean McGhee, Talal A Chatila
Affiliations
Review

Immunoglobulin replacement therapy in children

Maria Garcia-Lloret et al. Immunol Allergy Clin North Am. 2008 Nov.

Abstract

The benefit of immunoglobulin (IG) replacement in primary antibody deficiencies is unquestionable. Many of these congenital disorders present early in life and this therapy is often first implemented in the young. This article focuses on the indications of IG replacement in children, with an emphasis on the specific diagnostic problems encountered in this population. Also presented is an overview of the practical aspects of IG administration in the pediatric setting, including the recognition and management of adverse reactions. Finally, the advent of subcutaneous IG, a therapeutic IG modality with the potential to have a great impact on the quality of life of children with antibody deficiencies and their families, is discussed.

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References

    1. Jolles S, Sewell WA, Misbah SA. Clinical uses of intravenous immunoglobulin. Clin Exp Immunol. 2005;142:1. - PMC - PubMed
    1. Mahadevia PJ. The pocketbook: Pharmacoeconomic issues related to intravenous immunoglobulin therapy. Pharmacotherapy. 2005;25:94S. - PubMed
    1. Nimmerjahn F, Ravetch JV. Anti-inflammatory actions of intravenous immunoglobulin. Annu Rev Immunol. 2008;26:513. - PubMed
    1. Orange JS, Hossny EM, Weiler CR, et al. Use of intravenous immunoglobulin in human disease: a review of evidence by members of the Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and Immunology. J Allergy Clin Immunol. 2006;117:S525. - PubMed
    1. Clynes R. Protective mechanisms of IVIG. Curr Opin Immunol. 2007;19:646. - PubMed