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Review
. 2008 Nov;191(5):1570-5.
doi: 10.2214/AJR.07.3482.

Chest radiographic and CT manifestations of chronic granulomatous disease in adults

Myrna C B Godoy  1 , Patrick M Vos, Peter L Cooperberg, Carmen P Lydell, Peter Phillips, Nestor L Müller
Affiliations
Review

Chest radiographic and CT manifestations of chronic granulomatous disease in adults

Myrna C B Godoy et al. AJR Am J Roentgenol. 2008 Nov.

Abstract

Objective: The purpose of this study was to describe the thoracic radiologic findings of chronic granulomatous disease in adults.

Materials and methods: We retrospectively analyzed the chest radiographic and CT findings in four adults with chronic granulomatous disease during five episodes of lower respiratory tract infection.

Results: Chest radiographic findings included areas of consolidation (60%), diffuse reticulonodular opacities (40%), pleural effusion (20%), and pulmonary artery enlargement (20%). CT findings included areas of consolidation (60%), pulmonary nodules in a random distribution (60%), centrilobular nodules (60%), tree-in-bud opacities (40%), areas of scarring and traction bronchiectasis (100%), emphysematous changes (75%), areas of decreased attenuation and vascularity associated with air trapping on expiratory CT (50%), mediastinal and/or hilar lymphadenopathy (60%), pulmonary artery enlargement (50%), and pleural effusion (20%). Areas of consolidation and nodules were the most prominent findings and at histologic examination were found to be associated with infection or granulomatous inflammation.

Conclusion: The pulmonary radiologic findings of chronic granulomatous disease include consolidation, nodules, areas of scarring, traction bronchiectasis, emphysema, air trapping, mediastinal and hilar lymphadenopathy, pulmonary artery enlargement, and pleural effusion.

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