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Comparative Study
. 1991 Oct;59(10):3832-5.
doi: 10.1128/iai.59.10.3832-3835.1991.

Comparison of pertussis toxin (PT)-neutralizing activities and mouse-protective activities of anti-PT mouse monoclonal antibodies

H Sato  1 , Y Sato, I Ohishi
Affiliations
Comparative Study

Comparison of pertussis toxin (PT)-neutralizing activities and mouse-protective activities of anti-PT mouse monoclonal antibodies

H Sato et al. Infect Immun. 1991 Oct.

Abstract

An assay of neutralizing activity against CHO cell-clustering activity, one of the most common assays for anti-pertussis toxin antibodies, did not correlate well with an assay of the protective activities of monoclonal antibodies. A better correlation between neutralization of leukocytosis-promoting or islet-activating activity and mouse protection against aerosol challenge was seen.

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