doi: 10.1111/j.1399-3011.1991.tb00749.x.
Diastereoselective hydrolysis of peptide esters by alkaline protease. Preparation of racemization-free peptides
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- PMID: 1894450
- DOI: 10.1111/j.1399-3011.1991.tb00749.x
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Diastereoselective hydrolysis of peptide esters by alkaline protease. Preparation of racemization-free peptides
Int J Pept Protein Res.
1991 Apr.
Abstract
A new and practical enzymatic procedure for preparative diastereoselective hydrolysis of peptide esters using the alkaline protease alcalase as a catalyst was developed. This procedure has been successfully applied to the resolution of peptide diastereomers and synthesis of racemization free peptides.
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