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. 1991 Apr;37(4):347-50.
doi: 10.1111/j.1399-3011.1991.tb00749.x.

Diastereoselective hydrolysis of peptide esters by alkaline protease. Preparation of racemization-free peptides

S T Chen  1 , S H Wu, K T Wang
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Diastereoselective hydrolysis of peptide esters by alkaline protease. Preparation of racemization-free peptides

S T Chen et al. Int J Pept Protein Res. 1991 Apr.

Abstract

A new and practical enzymatic procedure for preparative diastereoselective hydrolysis of peptide esters using the alkaline protease alcalase as a catalyst was developed. This procedure has been successfully applied to the resolution of peptide diastereomers and synthesis of racemization free peptides.

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