Valproate in combat-related posttraumatic stress disorder

Abstract

Background: The symptoms of posttraumatic stress disorder (PTSD) suggest sympathetic nervous system hyperarousal and hyperreactivity. Pathophysiology of this condition may include stress-activated limbic kindling. Antikindling agents lithium and carbamazepine have been found effective for PTSD symptoms of intrusive reexperiencing and increased arousal. These facts suggest that valproate, another drug shown to interfere with limbic kindling, could also be effective for treatment of PTSD.

Method: An open clinical trial of valproate was conducted in 16 Vietnam veterans diagnosed with DSM-III-R combat-related PTSD.

Results: Ten of 16 patients showed significant improvement, especially in hyperarousal/hyperreactivity symptoms.

Conclusions: The efficacy of valproate in the treatment of PTSD should be rigorously studied.