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. 2009 Jan;32(1):91-3.
doi: 10.2337/dc08-1609. Epub 2008 Oct 22.

Effect of protein kinase Cbeta inhibition on renal hemodynamic function and urinary biomarkers in humans with type 1 diabetes: a pilot study

David Z I Cherney  1 , Ana Konvalinka, Bernard Zinman, Eleftherios P Diamandis, Anton Soosaipillai, Heather Reich, Joanne Lorraine, Vesta Lai, James W Scholey, Judith A Miller
Affiliations

Effect of protein kinase Cbeta inhibition on renal hemodynamic function and urinary biomarkers in humans with type 1 diabetes: a pilot study

David Z I Cherney et al. Diabetes Care. 2009 Jan.

Abstract

Objective: The aim of this study was to examine the effect of protein kinase Cbeta inhibition with ruboxistaurin on renal hemodynamic function and urinary biomarkers (monocyte chemoattractant protein-1 [MCP-1] and epidermal growth factor) in renin angiotensin system blockade-treated type 1 diabetic subjects.

Research design and methods: Albuminuric subjects were randomized (2:1) to ruboxistaurin (32 mg daily; n = 13) or placebo (n = 7) for 8 weeks. Renal hemodynamic function was measured during clamped euglycemia or hyperglycemia and before and after ruboxistaurin or placebo.

Results: Ruboxistaurin was not associated with between-group differences during clamped euglycemia or hyperglycemia. In a post hoc analysis comparing hyperfilterers with normofilterers during euglycemia, glomerular filtration rate and MCP-1 decreased, whereas the epidermal growth factor-to-MCP-1 ratio increased in hyperfilterers versus normofilterers (all P < 0.05).

Conclusions: The effect of ruboxistaurin is modest and dependent, at least in part, on the level of ambient glycemia and baseline glomerular filtration rate.

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Figures

Figure 1
Figure 1
The effect of ruboxistaurin (RBX) on GFR during euglycemia in hyperfiltration and normofiltration subjects (mean ± SEM). HF, hyperfiltration; NF, normofiltration. *P = 0.009 vs. baseline in hyperfiltration subjects. †P = 0.003 vs. response in normofiltration subjects.
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