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Review
. 2008 Oct 23;359(17):1811-21.
doi: 10.1056/NEJMra0800885.

Uric acid and cardiovascular risk

Daniel I Feig  1 , Duk-Hee Kang, Richard J Johnson
Affiliations
Review

Uric acid and cardiovascular risk

Daniel I Feig et al. N Engl J Med. .

Erratum in

  • N Engl J Med. 2010 Jun 10;362(23):2235
No abstract available

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Figures

Figure 1
Figure 1. Proposed Mechanism for Uric Acid–Mediated Hypertension
Excessive intake of fructose or purine-rich meats or exposure to low doses of lead may result in chronic hyperuricemia. Mothers with high uric acid levels that are the result of diet or conditions such as preexisting hypertension, obesity, or preeclampsia may transfer uric acid into the fetal circulation through the placenta, which may ultimately contribute to intrauterine growth retardation (IUGR) and a reduction in nephron number. Among babies born with a low nephron number, hyperuricemia may develop in childhood because of genetic or environmental factors. Chronic hyperuricemia would stimulate the renin–angiotensin system and inhibit release of endothelial nitric oxide, contributing to renal vasoconstriction and possibly increasing blood pressure. Persistent renal vasoconstriction may contribute to arteriolosclerosis and the development of salt-sensitive hypertension, even if the hyperuricemia is corrected. ROS denotes reactive oxygen species.
See this image and copyright information in PMC

Comment in

  • Uric acid and cardiovascular risk.
    Leow MK. Leow MK. N Engl J Med. 2009 Jan 29;360(5):538-9; author reply 540-1. doi: 10.1056/NEJMc082360. N Engl J Med. 2009. PMID: 19179326 No abstract available.
  • Uric acid and cardiovascular risk.
    Parmar MS. Parmar MS. N Engl J Med. 2009 Jan 29;360(5):539; author reply 540-1. N Engl J Med. 2009. PMID: 19186310 No abstract available.
  • Uric acid and cardiovascular risk.
    Bueno C. Bueno C. N Engl J Med. 2009 Jan 29;360(5):539; author reply 540-1. N Engl J Med. 2009. PMID: 19186311 No abstract available.
  • Uric acid and cardiovascular risk.
    Trivedi N. Trivedi N. N Engl J Med. 2009 Jan 29;360(5):539; author reply 540-1. N Engl J Med. 2009. PMID: 19186312 No abstract available.
  • Uric acid and cardiovascular risk.
    Hebert LA, Rovin B. Hebert LA, et al. N Engl J Med. 2009 Jan 29;360(5):540; author reply 540-1. N Engl J Med. 2009. PMID: 19186313 No abstract available.
  • Uric acid and cardiovascular risk.
    Oh J, Won HY, Kang SM. Oh J, et al. N Engl J Med. 2009 Jan 29;360(5):539-40; author reply 540-1. N Engl J Med. 2009. PMID: 19186314 No abstract available.

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