[Cell-free plasmic DNA as a blood factor determining hemodynamics in health and in vascular pathology]

Abstract

The article reviews investigations performed in the Research Neurology Institute on blood flow biomechanics which resulted in discovery of a universal permanent theological blood factor--circulating cell-free plasmic DNA reducing hydrodynamic blood resistance in accordance with Toms' effect. In vitro and in vivo experiments were made with use of drag-reducing polymers for correction of circulation. Basic mechanisms were discovered by which cell-free DNA regulates normal and affected circulation. Clinico-experimental investigations demonstrated the role of imbalance between DNA concentration in blood plasma and length of its fragments caused by their change in cerebrovascular diseases, in disorder of circulation pattern. It was shown in animal experiments that it is possible to correct abnormal circulation characteristics in ischemic disorders of brain circulation by intravenous injections of high-molecular DNA solutions.