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Randomized Controlled Trial
. 2008 Oct;10(5):586-8.

[Early use of recombinant human erythropoietin promotes neurobehavioral development in preterm infants]

[Article in Chinese]
Jin-Shui He  1 , Zhong-Ling Huang, Hong Yang, Kai-Zhi Weng, Shao-Bo Zhu
Affiliations
  • PMID: 18947475
Randomized Controlled Trial

[Early use of recombinant human erythropoietin promotes neurobehavioral development in preterm infants]

[Article in Chinese]
Jin-Shui He et al. Zhongguo Dang Dai Er Ke Za Zhi. 2008 Oct.

Abstract

Objective: To evaluate the effect of the early use of recombinant human erythropoietin (rhu-EPO) on neurobehavioral development in preterm infants.

Methods: Forty-four preterm infants (30 males and 14 females) were randomly divided into two groups: Rhu-EPO treatment and untreated control (n=22 each). From postnatal day 7, the Rhu-EPO treatment group received intravenous rhu-EPO (250 IU/kg3 times weekly) for 4 weeks. A Neonatal Behavioral Neurological Assessment (NBNA) was performed at 40 weeks of corrected gestational age. A Gesell Development Schedule was used to evaluate neurological development 6 and 12 months after birth.

Results: The NBNA score in the rhu-EPO treatment group (36.20+/-0.75) was significantly higher than that in the control group (34.40+/-1.05) at 40 weeks of corrected gestational age (P<0.05). The developmental quotient of fine motor in the rhu-EPO treatment group was significantly higher than that in the control group 6 months after birth (P<0.05). By 12 months after birth, the developmental quotient of gross motor, fine motor and language in the rhu-EPO treatment group was significantly higher than that in the control group (P<0.05).

Conclusions: Early use of Rhu-EPO can promote neurobehavioral development in preterm infants.

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